![]() ![]() ![]() The histologic features of GAS include clear and pale eosinophilic cytoplasm, distinct cell borders, and immunohistochemical evidence of gastric differentiation (expression of MUC6 and HIK1083). Minimal deviation adenocarcinoma (MDA), also known as adenoma malignum, is a designation that refers to a well-differentiated form of GAS. GAS is defined as a subtype of mucinous adenocarcinoma with gastric differentiation in the 2014 World Health Organization classification of cervical tumors. However, the remaining 5–10% of cervical adenocarcinomas are not associated with HPV infection, and the most common one is gastric-type adenocarcinoma (GAS). More than 90% of cervical adenocarcinomas are caused by high-risk human papillomavirus (HPV) persistent infection, with the most common HPV types as 18, 16 or 45. Therefore, awareness of the morphologic features and immunohistochemical profile of GAS will allow pathologists to recognize and accurately diagnose this rare and aggressive entity. ConclusionsĮndocervical GAS shows different morphologic and immunological features from endocervical usual type adenocarcinoma, but it may be difficult to be differentiated from metastatic mucinous adenocarcinoma to cervix due to similar morphology and overlapping immunohistochemical profile. P16 was negative or patchy positive in most cases and p53 mutation was identified in 12 cases (12/21, 57.1%). Immunohistochemically, tumor cells were diffusely positive for CK7, MUC6 and CA-IX, but focally positive for CK20 and CDX2. Ovarian and fallopian tube involvement were identified in 5 and 6 cases, respectively. Fourteen endocervical GAS cases demonstrated mild cytologic atypia, and 9 cases showed moderate to marked cytologic atypia. Cytologically, tall columnar epithelial cells with pale, foamy or vacuolated cytoplasm were mostly common, followed by well-defined cytoplasmic borders. The average age of patients was 51 years old (range from 28 to 73). Clinical characteristics, cytologic/histopathologic findings, and immunohistochemical results were collected and analyzed. MethodsĪ total of 23 patients diagnosed with endocervical GAS/minimal deviation adenocarcinoma (MDA) at Peking University People’s Hospital between 20 were included. This study aimed to evaluate cytologic and clinicopathological features, differential diagnosis of endocervical GAS. Aggressive treatment is justified in patients with pattern C tumors.Endocervical gastric-type adenocarcinoma (GAS) is a rare non-human papillomavirus-associated adenocarcinoma (NHPVA) with morphologic and immunohistochemical features of gastric differentiation. Patients with pattern B tumors rarely presented with metastatic LNs, and sentinel LN examination could potentially identify these patients. This new classification system demonstrated 20.7% of patients (pattern A) with negative LNs, and patients with pattern A tumors can be spared of lymphadenectomy. The 189 (53.7%) remaining patients had pattern C tumors 45 (23.8%) of them had LN metastases. Ninety patients (25.6%) were identified with pattern B tumors (all stage I) only 4 (4.4%) had LN metastases 1 had vaginal recurrence. Using this new system, 73 patients (20.7%) were identified with pattern A tumors (all stage I) none had LN metastases and/or recurrences. Forty-nine (13.9%) cases demonstrated lymph nodes (LNs) with metastatic endocervical carcinoma. Mean patient age was 45 years (range, 20 to 83 y). In total, 352 cases (all FIGO stages) from 12 institutions were identified. Tumors with pattern C showed diffusely infiltrative glands with associated extensive desmoplastic response. Pattern B tumors demonstrated localized destructive invasion defined as desmoplastic stroma surrounding glands with irregular and/or ill-defined borders or incomplete glands and associated tumor cells (individual or small clusters) within the stroma. In short, pattern A tumors were characterized by well-demarcated glands frequently forming clusters or groups with relative lobular architecture. A new 3-tier pattern-based system to classify endocervical adenocarcinoma was recently presented.
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![]() With updates to Metal backend support, you can train a wider set of networks faster with new features like custom kernels and mixed-precision training. Integrate CoreML and ONNX models into your Metal app faster with MPS Graph conversion tools, and load native MPS Graph models more quickly with the new serialization format.Īccelerate the training of machine learning models right on your Mac with TensorFlow, PyTorch, and now JAX. The Metal debugger adds support for mesh shader geometry visualization and shader debugging of object and mesh shaders. ![]() Our goal is to provide the best user and shopping experience that Mac gamers deserve with fun new selections. The shader validation tool now detects out-of-bounds memory accesses from object and mesh shaders. MacGameStore was formally launched in April 2005 (from its original format of the Inside Mac Games store), and since then has grown into a leading Mac distributor of digital download games with over a million Mac games sold. Multiple levels of instancing and curve primitive support deliver more efficient representation of complex materials such as trees, hair, and fur.ĭebug your mesh shader pipelines with Xcode 15. Scale your games and production renderers to even more realistic and detailed scenes. Provide smooth frame rates and more responsive interactions using the new CAMetalDisplayLink. Metal Developer Tools for Windows 4 beta.Now, the GPU binary compiler supports ray tracing and dynamically linked libraries with a toolchain for macOS or Windows. ![]() Generate GPU binaries at build time and eliminate in-app shader compilation, improve game performance, and reduce load times. This year, MetalFX Upscaling supports more devices with improved quality and increased scaling. Render complex scenes in less time per frame with high-performance upscaling and anti-aliasing. Use the game porting toolkit to eliminate months of up-front work and evaluate how well your game could run on Mac before writing any code.Ĭonvert your shaders and graphics code so that your game can take full advantage of the powerful features and performance of Apple silicon. We also looked for healthy, safe options, especially when choosing food or treats. During our 15-hour search, we looked for items that would do one of those things, which should also improve the relationship with your furry companions. Either they enrich the life of your pets, or they make your job easier as their owner and caregiver. Pets The best pet products usually do one of two things.Top 10 Best Survival Gear #1 TG USB Rechargeable Plasma… Keep reading to learn more about other high-grade survival gear available for purchase. Our “honorable mention” is the TG USB Flameless Arc Lighter because it can reliably create fire even in inclement weather or extreme conditions. It includes just about anything one would need to stay safe while out in the wilderness, during an emergency, or in a survival situation. ![]() TG Plasma Lighter Windproof Waterproof USB… Check Price Sale Go Time Gear Life Tent Emergency Survival Shelter… Check Price Sale Vont 2 Pack LED Camping Lantern, Super Bright… Check Price Our top pick, and the number one item that everyone should consider owning, is the Kosin 18-in-1 Emergency Survival Pack. Every piece of gear or equipment we chose will vastly improve the survivability of anyone carrying it. During our 10 hour search, we looked for some of the most practical gear options like emergency supplies, food, and water options, and more. Often, they include tools or equipment, which improve safety, health, and resourcefulness while out in the wilds.
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![]() ![]() Just like our previous series this sees the addition of six more models in the minisize. Along his senior staff of officers he has experienced a lot of adventures in his long Starfleet career. Kirk has been in command of the first Enterprise to bear the registration NCC-1701 and her successor NCC-1701-A. Unfortunately his own family in form of his mother, brother and nephew do know how to prevent him from achieving just that. Quark: This Ferengi business man owns and runs a bar on the promenade of Deep Space Nine and tries to follow the rules of acquisition to amass maximum profit.Taking humankind to court in the TNG pilot episode, Q turned out to be more of a joker in subsequent appearances. ![]() Q: The almost omnipotent being from the Q continuum found a favorite opponent in Captain Jean-Luc Picard.Seven of Nine: The former Borg drone found a new home on the USS Voyager NCC-74656 and helps the crew with at times unconventional methods and her vast knowledge of the Delta quadrant.Enterprise NCC-1701-D comes with a PADD and his trusty cat Spot who did cost his fellow senior officers some nerves while pet sitting. Captain Benjamin Sisko: Commanding officer of Deep Space Nine equipped with phaser, baseball and baseball glove.Having added Brick Buddies in our Series 4 as a new category of sets we do add six more main and recurring characters with our Series 5. No matter if the chief medical officer is one of flesh and blood or an emergency medical hologram all are very likely to use a medical tricorder for diagnosing their many patients and needing to apply them with some hypospray for medication. If you prefer text you can find all the information about all upcoming sets in their proper colors below: Props for sick bayĪfter supplying the security department on Starfleet vessels and Klingon warriors with plenty of weaponary with our previous props, now officers doning blue uniforms do get their proper equipment. In our video Marco and Dirk present all the colorful prototypes in our most recent preview video: As always you can find all of the upcoming sets in our Star Trek category and sign up for a release notfication via email. Also we have another shuttle in the mini figure scale and an advent calendar waiting for you this holiday season. In our most recent preview video and in this very blog post you will learn which much wanted sets are awaiting as upcoming full scale props, Brick Buddies, mini-, midsize- and display size models. The current Series 4 of our Star Trek models didn't fully go to retail yet and we do present a preview of the Series 5 sets already? Oh yes, we sure do. Star Trek Series 5 - These sets are coming next! In-game screenshot: Artifacts are a great help in Ninja Arashi 2 There are 8 artifacts available in the game, The Onimori, the Akumu, the Sword of Tatsuma, the Coin of Luck, the Golden Shuriken, the Dotaku, the Meiyo, and the Sacred Tsuka. In other words, these artifacts provide added benefits to your gameplay whenever you use them. What are the Artifacts?Īnother new thing that Ninja Arashi 2 introduced is the artifacts or hidden attribute boosters. The added benefits can especially help you during boss battles. ![]() This will help you greatly, especially in the higher levels when things become more difficult. You can see what added benefit or trait you’ll get after you make an upgrade. You use coins to upgrade your skills, so you’ll need to save your coins for these skills. In-game Screenshot: Upgrade skills in Ninja Arashi 2 to make abilities stronger Another upgrade will unlock the plunder, and so on. For example, the shuriken throw/sword slash ability will gain a critical strike after 1 upgrade. Each ability Arashi has will have certain added benefits whenever upgraded. It’s basically a new menu where you can upgrade the abilities that Arashi has to improve his stats and attributes. ![]() One of the new elements introduced in Ninja Arashi 2 is the Skill. It will provide tips on how to properly play the game, as well as an explanation of the new elements it introduces. To help avoid having a bad start or bad experience playing the game, this blog post will be a Ninja Arashi 2 beginners guide. ![]() This could cause a bit of confusion for beginners. Nevertheless, despite having a tutorial and similar gameplay with the first installment, there are still new elements to Ninja Arashi 2. So even if this is your first time playing the second installment, you won’t have trouble since there will be a tutorial to guide you. The gameplay for both games is also similar. The second game features the same appealing graphics, with its black silhouette characters and awesome background. This time, he’ll be battling the villain Dosu while trying to rescue his son. Though the first game did end in a cliffhanger, the second installment, Ninja Arashi 2, aims to continue the retired ninja’s story. For gamers who have played the Ninja Arashi game, it’s clear to say that the game has been a fun and exciting action adventure. ![]() ![]() ![]() So programmes like McAfee, Adobe or Skype shouldn’t be on your desktop at all. Some people don’t realise that when they add a programme or receive an upgrade, the provider automatically adds the icon to their desktop. Most of the icons don’t need to be there at all and, when I’ve asked them why they have so many, they didn’t even know they weren’t vital to the running of their PC. They look like the image above which is actually the type of thing that’ll give a minimalist like myself nightmares. Mailplane’s new share extension allows users to share files, urls and text from various applications (e.g.When I use a clients computer I often shudder at how cluttered their desktops are. Photos, Pages, Numbers, Safari, TextEdit, etc.). Todoist is a popular to-do list and task manager. With Mailplane you can easily create tasks based on Gmail conversations (it isn’t supported in Google Inbox due to technical limitations). The OmniFocus web add-on subscriptions exist for customers who already own a standalone app, but wish to add web access. OmniFocus is a great “Getting Things Done” tool and with Mailplane you can easily create tasks based on Gmail conversations. The web add-on subscription is only available through the Omni Store. Subscriptions are managed through your Omni account. An existing license for OmniFocus for Mac or iOS is required for the web app to work. Mailplane provides a print dialog action to send a PDF from any application. Unfortunately, 3rd party applications like Mailplane aren’t allowed to support the Share > Email functionality in iWork/MS Office anymore. Below you’ll find a short description how you can work around it and still share iWork / Office documents easily via Email.Īlfred (v.2.0.3) and later supports Mailplane 3 out of the box. It’s very easy to create a new to-dos based on email conversations. Most importantly, Things creates a to-do that links back to the Gmail conversation. Remember and track your email conversations with Evernote. Manage all your Gmail, Calendar and Contacts accounts in Mailplane instead of cluttering up your browser window. LaunchBar uses service menu items as actions. Here’s how you can create an email w/ attachments from Launchbar 5:ĪppleScript is a scripting language built into MacOS. It is primarily designed to exchange data between applications in order to automate repetitive tasks. Terminal.app comes pre-installed and you’ll find it in Applications > Utilities.Īccess Mailplane’s service menu items from any application to send messages or search your inbox. GrandTotal, an invoicing application for designers, lets you email your invoices. What is Mailplane You like threaded conversations, googling your inbox, and you prefer labels over folders. Receipts is the perfect companion to Mailplane if you receive a lot of invoices via email. It makes it easy to collect and classify them.įantastical sends events through Mailplane.ĭEVONthink Pro is the one store for all your documents.īus圜al can send meeting invitations through Mailplane.īus圜ontacts can send messages to contacts or cards through Mailplane. ![]() Use "Edit > Save to Contact" to save the sender to Contacts app and use "Mail > Insert > Email Address." to lookup email addresses in Contacts app while composing or replying to a message. Lyn, a fast and lightweight image browser, lets you directly email pictures. Triage email into OmniFocus using built-in tools, or the Omni Sync Servers. GraphicConverter displays and edits raster graphics files. Mailplane is a Gmail- (or Google Apps) specific app that combines the native. It also converts files between different formats. For example, one can convert a GIF file to a JPEG file. ![]() ![]() Each room is small, and it only takes a few minutes to read the information, but there are a lot of rooms, so expect to spend an hour if you want to read everything. Keep in mind, the name on the record will be the name your ancestor used in their country of. Topics include the medical, legal, and health inspections medical care and the Ellis Island hospital the ticket office the currency exchange room immigrant aide detention and the Ellis Island dining room where immigrants could get a meal while waiting for inspection or to take with them once they were allowed to leave Ellis Island.Īs with the Peak Immigration Years, much of the Through America’s Gate exhibit is comprised of historical photos, reprints of posters and documents, and quotes from both employees and immigrants at Ellis Island. You can view these records in person at Ellis Island or online. Housed in a series of small rooms that were once used for legal hearings, waiting rooms, detention quarters, and staff offices, the exhibits focus on the different steps that most immigrants had to go through in order to be granted admission into the United States. announced August 14, 2018, the entire collection of Ellis Island New York Passenger Arrival Lists from 1820 to 1957 is available online on both websites.On the opposite side of the Registry Room from the Peak Immigration Years museum gallery is another exhibit area not to be missed, Through America’s Gate. FamilySearch and the Statue of Liberty–Ellis Island Foundation, Inc. Today it is known as Castle Clinton National Park, a 25-acre waterfront historical park located within the Battery, one of New York City’s oldest parks and the departure point for tourists visiting the Statue of Liberty and Ellis Island. The ship manifests list passengers, their names, age, last place of residence, who is sponsoring them in America, the port of departure, their date of arrival in New York Harbor, and sometimes other interesting information, such as how much money they carried on them, number of bags, and where on the ship they resided during its sail from overseas, according to the joint press release.Įllis Island’s predecessor-Castle Garden-was actually America’s first immigration center.
![]() Their engineers inspect your drive and then, they provide you with a price quote alongside a turnaround estimate as well as a list of all the files that could be recovered. When you contact Secure Data Recovery for lost data, your case is handled by experts in the field.įor users who are wondering how Secure Data Recovery helps to recover data, recovery is arranged through an online form. To put in simple words, they can assist you to access any files you may have lost. RAID data recovery and other RAID services.Data Recovery for SSD, and flash drives.They can help you perform the following recoveries: With a team of knowledgeable and experienced engineers, Secure Data Recovery provides a solution to recover lost data. For users who are still wondering what to expect from them, below is an in-depth Secure Data Recovery reviews from several different aspects. It's no secret that Secure Data Recovery is the top choice for people who would like to recover lost data. Part 2: The Most Comprehensive Secure Data Recovery Reviews ![]() If your hard drive is dead or damaged, then you can send it to the Secure Data Recovery lab to get back your valuable data from the damaged hard drive.Ĭontinue reading to know more about Secure Data Recovery services and how they can help you recover your lost data. They have experienced engineers, the industry's leading data repair facilities and a certified Class 10 ISO 4 Classroom. They provide service for data recovery, RAID repair, hard drive repair, computer forensics, and many other media services in their safe and clean room. Part 3: Better Choice than Secure Data Recovery to Recover Lost Dataįounded in 2007, Secure Data Recovery is one of the leading companies that offer professional data recovery services.Part 2: The Most Comprehensive Secure Data Recovery Reviews. Try not to stick them inside a desk, behind your computer monitor, or way back in a corner. Make sure to position it well: A standalone router or gateway should sit as close to the center of your home as possible and out in the open, but all routers and satellites should have as few obstructions around them as possible (especially metal ones).But these common troubleshooting and maintenance tips should help you keep your network running as smoothly and securely as possible. Routers are complicated pieces of technology, and we can’t tell you everything you’d need to know to fix every networking problem you might run into. Troubleshooting and maintaining your router or gateway If you want to know more about the way your router does its job, this summary of common networking terminology is a good place to start. You can add more satellites to the network later if you’re still unhappy with the coverage in certain parts of your home or if you move to a bigger place. Unlike traditional Wi-Fi extenders, which don’t coordinate with your router, these mesh Wi-Fi systems are developed to work together they make sure that each of your devices is connected to the router or satellite that provides the best, strongest signal. ![]() If you have a DSL or fiber internet connection, your ISP is likely to require you to use its provided modem, which usually serves as a gateway and router as well, and the situation is more complicated if you also get phone service from your ISP. Typically you can save $5 to $15 on your monthly internet bill if you use your own modem and router instead of the equipment your cable provider offers. But you might need to replace a router because you want better coverage, because you’ve added more devices to your network and your old router isn’t keeping up, or because you want to take advantage of the latest improvements in Wi-Fi technology, which can change more often than modem standards do. Modem technology changes slowly, and you can usually use a modem for years until it breaks. You need the features of both a modem and a router, integrated or not, in order to have an internet connection for all of the devices in your home.įor people who have internet access provided by a cable company (and who don’t have gigabit or higher internet speeds), we recommend using a separate modem and router if possible. ![]() Often, your internet service provider will give you a device typically referred to as a gateway, a single box that serves as both modem and router, but these are still different technologies. A router is a box that lets all of your wired and wireless devices use that internet connection at once and allows them to talk to one another directly. A modem is a box that connects your home network to your internet service provider, or ISP. While both a modem and a router help your devices connect to the internet, they have separate (and complementary) functions. |
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