![]() ![]() ![]() The histologic features of GAS include clear and pale eosinophilic cytoplasm, distinct cell borders, and immunohistochemical evidence of gastric differentiation (expression of MUC6 and HIK1083). Minimal deviation adenocarcinoma (MDA), also known as adenoma malignum, is a designation that refers to a well-differentiated form of GAS. GAS is defined as a subtype of mucinous adenocarcinoma with gastric differentiation in the 2014 World Health Organization classification of cervical tumors. However, the remaining 5–10% of cervical adenocarcinomas are not associated with HPV infection, and the most common one is gastric-type adenocarcinoma (GAS). More than 90% of cervical adenocarcinomas are caused by high-risk human papillomavirus (HPV) persistent infection, with the most common HPV types as 18, 16 or 45. Therefore, awareness of the morphologic features and immunohistochemical profile of GAS will allow pathologists to recognize and accurately diagnose this rare and aggressive entity. ConclusionsĮndocervical GAS shows different morphologic and immunological features from endocervical usual type adenocarcinoma, but it may be difficult to be differentiated from metastatic mucinous adenocarcinoma to cervix due to similar morphology and overlapping immunohistochemical profile. P16 was negative or patchy positive in most cases and p53 mutation was identified in 12 cases (12/21, 57.1%). Immunohistochemically, tumor cells were diffusely positive for CK7, MUC6 and CA-IX, but focally positive for CK20 and CDX2. Ovarian and fallopian tube involvement were identified in 5 and 6 cases, respectively. Fourteen endocervical GAS cases demonstrated mild cytologic atypia, and 9 cases showed moderate to marked cytologic atypia. Cytologically, tall columnar epithelial cells with pale, foamy or vacuolated cytoplasm were mostly common, followed by well-defined cytoplasmic borders. The average age of patients was 51 years old (range from 28 to 73). Clinical characteristics, cytologic/histopathologic findings, and immunohistochemical results were collected and analyzed. MethodsĪ total of 23 patients diagnosed with endocervical GAS/minimal deviation adenocarcinoma (MDA) at Peking University People’s Hospital between 20 were included. This study aimed to evaluate cytologic and clinicopathological features, differential diagnosis of endocervical GAS. Aggressive treatment is justified in patients with pattern C tumors.Endocervical gastric-type adenocarcinoma (GAS) is a rare non-human papillomavirus-associated adenocarcinoma (NHPVA) with morphologic and immunohistochemical features of gastric differentiation. Patients with pattern B tumors rarely presented with metastatic LNs, and sentinel LN examination could potentially identify these patients. This new classification system demonstrated 20.7% of patients (pattern A) with negative LNs, and patients with pattern A tumors can be spared of lymphadenectomy. The 189 (53.7%) remaining patients had pattern C tumors 45 (23.8%) of them had LN metastases. Ninety patients (25.6%) were identified with pattern B tumors (all stage I) only 4 (4.4%) had LN metastases 1 had vaginal recurrence. Using this new system, 73 patients (20.7%) were identified with pattern A tumors (all stage I) none had LN metastases and/or recurrences. Forty-nine (13.9%) cases demonstrated lymph nodes (LNs) with metastatic endocervical carcinoma. Mean patient age was 45 years (range, 20 to 83 y). In total, 352 cases (all FIGO stages) from 12 institutions were identified. Tumors with pattern C showed diffusely infiltrative glands with associated extensive desmoplastic response. Pattern B tumors demonstrated localized destructive invasion defined as desmoplastic stroma surrounding glands with irregular and/or ill-defined borders or incomplete glands and associated tumor cells (individual or small clusters) within the stroma. In short, pattern A tumors were characterized by well-demarcated glands frequently forming clusters or groups with relative lobular architecture. A new 3-tier pattern-based system to classify endocervical adenocarcinoma was recently presented.
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![]() With updates to Metal backend support, you can train a wider set of networks faster with new features like custom kernels and mixed-precision training. Integrate CoreML and ONNX models into your Metal app faster with MPS Graph conversion tools, and load native MPS Graph models more quickly with the new serialization format.Īccelerate the training of machine learning models right on your Mac with TensorFlow, PyTorch, and now JAX. The Metal debugger adds support for mesh shader geometry visualization and shader debugging of object and mesh shaders. ![]() Our goal is to provide the best user and shopping experience that Mac gamers deserve with fun new selections. The shader validation tool now detects out-of-bounds memory accesses from object and mesh shaders. MacGameStore was formally launched in April 2005 (from its original format of the Inside Mac Games store), and since then has grown into a leading Mac distributor of digital download games with over a million Mac games sold. Multiple levels of instancing and curve primitive support deliver more efficient representation of complex materials such as trees, hair, and fur.ĭebug your mesh shader pipelines with Xcode 15. Scale your games and production renderers to even more realistic and detailed scenes. Provide smooth frame rates and more responsive interactions using the new CAMetalDisplayLink. Metal Developer Tools for Windows 4 beta.Now, the GPU binary compiler supports ray tracing and dynamically linked libraries with a toolchain for macOS or Windows. ![]() Generate GPU binaries at build time and eliminate in-app shader compilation, improve game performance, and reduce load times. This year, MetalFX Upscaling supports more devices with improved quality and increased scaling. Render complex scenes in less time per frame with high-performance upscaling and anti-aliasing. Use the game porting toolkit to eliminate months of up-front work and evaluate how well your game could run on Mac before writing any code.Ĭonvert your shaders and graphics code so that your game can take full advantage of the powerful features and performance of Apple silicon. We also looked for healthy, safe options, especially when choosing food or treats. During our 15-hour search, we looked for items that would do one of those things, which should also improve the relationship with your furry companions. Either they enrich the life of your pets, or they make your job easier as their owner and caregiver. Pets The best pet products usually do one of two things.Top 10 Best Survival Gear #1 TG USB Rechargeable Plasma… Keep reading to learn more about other high-grade survival gear available for purchase. Our “honorable mention” is the TG USB Flameless Arc Lighter because it can reliably create fire even in inclement weather or extreme conditions. It includes just about anything one would need to stay safe while out in the wilderness, during an emergency, or in a survival situation. ![]() TG Plasma Lighter Windproof Waterproof USB… Check Price Sale Go Time Gear Life Tent Emergency Survival Shelter… Check Price Sale Vont 2 Pack LED Camping Lantern, Super Bright… Check Price Our top pick, and the number one item that everyone should consider owning, is the Kosin 18-in-1 Emergency Survival Pack. Every piece of gear or equipment we chose will vastly improve the survivability of anyone carrying it. During our 10 hour search, we looked for some of the most practical gear options like emergency supplies, food, and water options, and more. Often, they include tools or equipment, which improve safety, health, and resourcefulness while out in the wilds.
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![]() ![]() Just like our previous series this sees the addition of six more models in the minisize. Along his senior staff of officers he has experienced a lot of adventures in his long Starfleet career. Kirk has been in command of the first Enterprise to bear the registration NCC-1701 and her successor NCC-1701-A. Unfortunately his own family in form of his mother, brother and nephew do know how to prevent him from achieving just that. Quark: This Ferengi business man owns and runs a bar on the promenade of Deep Space Nine and tries to follow the rules of acquisition to amass maximum profit.Taking humankind to court in the TNG pilot episode, Q turned out to be more of a joker in subsequent appearances. ![]() Q: The almost omnipotent being from the Q continuum found a favorite opponent in Captain Jean-Luc Picard.Seven of Nine: The former Borg drone found a new home on the USS Voyager NCC-74656 and helps the crew with at times unconventional methods and her vast knowledge of the Delta quadrant.Enterprise NCC-1701-D comes with a PADD and his trusty cat Spot who did cost his fellow senior officers some nerves while pet sitting. Captain Benjamin Sisko: Commanding officer of Deep Space Nine equipped with phaser, baseball and baseball glove.Having added Brick Buddies in our Series 4 as a new category of sets we do add six more main and recurring characters with our Series 5. No matter if the chief medical officer is one of flesh and blood or an emergency medical hologram all are very likely to use a medical tricorder for diagnosing their many patients and needing to apply them with some hypospray for medication. If you prefer text you can find all the information about all upcoming sets in their proper colors below: Props for sick bayĪfter supplying the security department on Starfleet vessels and Klingon warriors with plenty of weaponary with our previous props, now officers doning blue uniforms do get their proper equipment. In our video Marco and Dirk present all the colorful prototypes in our most recent preview video: As always you can find all of the upcoming sets in our Star Trek category and sign up for a release notfication via email. Also we have another shuttle in the mini figure scale and an advent calendar waiting for you this holiday season. In our most recent preview video and in this very blog post you will learn which much wanted sets are awaiting as upcoming full scale props, Brick Buddies, mini-, midsize- and display size models. The current Series 4 of our Star Trek models didn't fully go to retail yet and we do present a preview of the Series 5 sets already? Oh yes, we sure do. Star Trek Series 5 - These sets are coming next! |
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